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function and is mediated by adult stem cells located in the basal layer of the epidermis. Meanwhile, it has become a global trend in cosmetics to protect or vitalize stem cells in the epidermis. Various in-vitro test systems using epi- dermal stem cells have been estab- lished, allowing claims for epidermal stem cell actives. Targeting dermal stem cells What about the stem cells in the dermis? Until now, cosmetic treat- ments have rarely addressed them de- spite the fact that they play a decisive role in skin ageing. Fibroblasts – the prominent cell type in the dermis – are responsible for continuously produc- ing collagen and elastin, which form the extracellular matrix and confer elasticity and firmness to the skin. Age- ing skin is characterized by an increas- ing number of senescent fibroblasts. These cells stop producing collagen and elastin and even start to break down the existing matrix. Only dermal stem cells can replace these senescent cells by new fibroblast cells. Stem cells have only recently been identified as helping to generate new fibroblast cells. These cells are now the focus of intense research in regenerative medi- cine and thus of interest for cosmetic treatments. It has been shown that the extract of Saponaria pumila plant stem cells in- creases the activity of dermal stem INGREDIENTS PRODUCTION through in natural cosmetics. This re- sulted in PhytoCellTec Nunatak, the active ingredient based on Saponaria pumila stem cells being named runner- up at the Organic Monitor’s interna- tional Sustainable Beauty Awards in November 2014. These awards recog- nize organizations that push the boundaries of sustainability in the beauty industry. The next generation of stem cell cosmetics Stem cells are unspecialized cells capable of self-renewing throughout the lifespan of the organism. Adult tis- sues contain multi- or unipotent stem cells, which indicate they can divide in- to more than one cell type or only one cell type respectively. These adult stem cells are responsible for a continuous supply of new cells that are essential for repair and regeneration. A perfect example of this is the epidermis, which is constantly renewed and repaired throughout life. This process is essen- tial to maintain the normal barrier photo:Mibelle E-mail newsletter order Please fill in completely in capital letters or add your business card: @ E-mail First name, family name Company Street address Postcode, city, country Date and signature z Yes, I want to be kept right up to date. I therefore agree that Health and Beauty Germany GmbH may contact me J by mobile phone J by e-mail J in writing J by telephone/fax with news from the industry and to tell me about inter- esting offers. If I do not wish to receive further infor- mation, I will communicate this to Health and Beauty. Order today: Fax: +49 (0)721 165-103 Health and Beauty Germany GmbH Karl-Friedrich-Str. 14–18 76133 Karlsruhe Germany leserservice@health-and-beauty.com Tel: +49(0) 721 165-131 Fax: +49(0) 721 165-103 Trends Statements Innovation The extract of Saponaria pumila plant stem cells increases the vitality of dermal stem cells and protects them from UV-induced stress Additional information can be found at www.cossmay.com/qr00007 or you can just scan the QR code! Your access codes for April: User name: cossma4 Password: body DownloadsDownloads Ī COS1504_38_Mibelle_GB_COS1409_30_Balluff_D 26.03.15 13:10 Seite 39 Fax: +49 (0)721165-103 Karl-Friedrich-Str. 14–1876133 Karlsruhe Germany Tel: +49(0) 721165-131 Fax: +49(0) 721165-103 COS1504_38_Mibelle_GB_COS1409_30_Balluff_D 26.03.1513:10 Seite 39