Cossma1607-08_GB

photo: Mayer George, Shutterstock.com pol- the stra- m or neo- lop- ince n is nor- ntal sive Evaluating the effects of pollutant-exposed products A new validated clinical method evaluates the “protective” effects of specific cosmetic products when exposed to gaseous pollu- tion. The skin of human volun- teers is treated with the product under test, exposed to cigarette smoke. In a next step peroxida- tion of human sebum or skin ­ barrier lipids are assessed using liquid chromatography-mass spectrometry (LC-MS). The key advantage of this method is the small number of volunteers re- quired, and the reproducibility and sensitivity of the method to detect protective and anti-oxida- tive properties of cosmetic active ingredients and cosmetic formula- tions. Furthermore, pollutant cig- arette smoke is a suitable sub- stance containing all key pollution components that can be used in human volunteers without ethical issues as compared to other pollu- tion sources. Our method enables us to induce a pollution stress on “living skin” under standardised clinical laboratory conditions. The effects of smoke on the skin Cigarette smoke is a highly com- plex mixture of thousands of chemical substances, including reactive oxygen species (ROS), ­ reactive nitrogen species and elec- trophilic aldehydes. Environmen- tal cigarette smoke contains car- cinogens and also a large amount of oxygen radical-producing sub- Cigarette smoke contains all key pollution compo- nents CIGARETTE SMOKE is a complex mix- ture of chemical substances, includ- ing reactive oxygen species (ROS), reac- tive nitrogen species and electrophilic ­ aldehydes SPOTLIGHT: ANTI-POLLUTION www.cossma.com  l  43 a.com NEGATIVE EFFECTS OF AIR POLLUTANTS The continual increase in air pollution is having major negative effects on human skin. Major air pollutants with consequential negative effects on the skin include solar ultraviolet radiation (UVR) and environmental air pollutants such as polycyclic aro- matic hydrocarbons (PAHs), oxides, volatile organic com- pounds (VOCs), noxious gases, particulate matter (PM), ozone (O3) and cigarette smoke. Cigarette smoking has been associated with skin ageing (wrinkles, skin dryness, skin discoloration, etc.), and the combination of smoking and sun exposure may even have a synergistic effect on the skin ageing processes. N N SunZnO Zinc Oxide range Natural and safe UV-filters NanoSCCS compliant and non nanogrades High UVA and UVB protection SunZnO-NAS SunZnO-SA Distributed by IMPAG Import GmbH Fritz-Remy-Straße 25 D-63071 Offenbach am Main Tel.: +49 (0) 69 850 008 - 0 Fax: +49 (0) 69 850 008 - 90 E-Mail: kosmetik@impag.de Web: www.impag.de IMPAG Group Country Offices Switzerland/Zurich – www.impag.ch Germany/Offenbach – www.impag.de France/Nancy – www.impag.fr Poland/Warsaw – www.impag.pl Austria /Vienna – www.impag.at one source one responsibility Now listed as UV-filter again! COS1607_42_Proderm_Antipol.indd 43 26.07.16 10:39 Tel.: +49 (0) 69850008 - 0 Fax: +49 (0) 69850008 - 90 COS1607_42_Proderm_Antipol.indd 4326.07.1610:39

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