6
FRESHSTAT
TM
(40% cetylpyridinium chloride in propylene glycol) is a
safe and versatile, surface-active, cationic additive with antimicrobi-
al action. Already at low application concentrations of around 0.25%,
FRESHSTAT
TM
exhibits very high efficacy against gram positive and
gram negative bacteria and against fungi, making it a possible alter-
native to parabens, triclosan, isothiazolinones, and formaldehyde-split-
ting substances in leave-on and rinse-off formulations.
The European Scientific Committee on Consumer Safety (SCCS) has
positively rated FRESHSTAT™ for use as an antimicrobial additive in cos-
metics
(Positive SCCS Opinion 0985/06)
.
FRESHSTAT™ exhibits
excellent effectiveness
against the
body-
odour-producing bacteria Corynebacterium jeikeium
and
Cory-
nebacterium xerosis
, and is therefore suitable for use in deodorizing
products such as roll-on, stick or soap deodorants.
Properties:
• Cationic co-surfactant, antistatic
• Broad spectrum activity already at low application concentrations
(0.25% of the 40% product)
• Biodegradable (OECD 307)
• Stable over a wide pH range (pH 4–10)
• Temperature stable up to 100 °C
• Easy to work into formulations
• FRESHSTAT™ is soluble in water and other polar solutions
• Booster effect when used with 0.1% EDTA
• No negative impact on the viscosity of the final product
• Not compatible with xanthan gum or anionic rinse-off systems
(SLES)
The colourless and odourless raw material is produced under cGMP con-
ditions.
Human safety:
• FRESHSTAT
TM
is US FDA approved and has approval for oral care ap-
plications
• Positive SCCS opinion (0985/06 for use as an antimicrobial additive
in cosmetics)
• The product causes no skin irritations at a tested application con-
centration of 0.5% (HRIPT 100 people 0.5% CPC in an O/W face care
application)
FRESHSTAT™
INCI:
Cetylpyridinium Chloride and Propylene Glycol
Appearance:
Clear liquid
Recommended application concentration:
0.25%–0.75%
Certificates:
cGMP, FSSC 22000, kosher and halal available
Formulation:
At the end of the production process
FRESHSTAT™
is a Vertellus product
IPD – a product of our new partner KURARAY – is an innovative multita-
lent for use in personal care applications. This water-soluble solvent im-
proves the sensory profile of finished products and creates a smooth,
non-sticky feel. The product is capable of solubilizing even troubleso-
me actives such as glycyrrhetinic acid or Boswellia serrata extract, and
allows the use of hydrophilic substances in water-free and lipophilic
substances in water-based systems. Adding IPD to perfume oils allows
the alcohol content to be significantly reduced, and allows the deve-
lopment of milder perfume or body sprays that stand out for a good
feel.
When IPD is worked into the water phase of an O/W emulsion, a more
even distribution and reduction of droplet sizes is observed, which po-
sitively affects the stabilizing properties of an O/W emulsion.
IPD has good wetting properties, as proven in tests with silica, iron pig-
ments and mineral UV filters such as titanium dioxide.
5% IPD worked into a compact powder formulation
significantly im-
proves elasticity, application characteristics and breakage resi-
stance
, while lipstick formulations can be optimized in terms of pay-off
and shine effect with 2.5–3%.
Combination with sorbitol creates synergistic effects to reveal both
moisturizing properties and a repairing action in tests on damaged hair.
Comparing the micrographs of a hair shaft treated for 30 minutes with
a 5% IPD and 5% sorbitol solution, a
significant improvement in the
hair structure
can be seen (see Figs. 9 and 10). IPD is excellent for use in
hair masks to
improve hair shine
and produce a softer, more groomed
feeling to the hair.
ISOPENTYLDIOL (IPD)
INCI:
Isopentyldiol
Appearance:
Transparent, slightly viscous liquid
Recommended application concentration:
2%–10%
ISOPENTYLDIOL (IPD)
is a Kuraray product
Fig 9: Before treatment with
5% IPD + 5% sorbitol
Fig 10: After treatment with
5% IPD + 5% sorbitol
F R E S H S TAT
T M
Effective antimicrobial additive
I S O P E N T Y L D I O L ( I PD)
Versatile emollient
